If the code does indeed have some logical foundation then it is legitimate to consider all the evidence, both good and bad, in any attempt to deduce it. Francis Crick attemptbadcode Change image and share on social
This seems highly likely, especially as it has been shown that in several systems mutations affecting the same amino acid are extremely near together on the genetic map. Francis Crick acidaffectamino Change image and share on social
If poly A is added to poly U, to form a double or triple helix, the combination is inactive. Francis Crick addcombinationdouble Change image and share on social
It now seems certain that the amino acid sequence of any protein is determined by the sequence of bases in some region of a particular nucleic acid molecule. Francis Crick acidaminobasis Change image and share on social
It seems likely that most if not all the genetic information in any organism is carried by nucleic acid - usually by DNA, although certain small viruses use RNA as their genetic material. Francis Crick acidcarrydna Change image and share on social
It would appear that the number of nonsense triplets is rather low, since we only occasionally come across them. However this conclusion is less secure than our other deductions about the general nature of the genetic code. Francis Crick codeconclusiondeduction share on social
Moreover the incorporation requires the same components needed for protein synthesis, and is inhibited by the same inhibitors. Thus the system is most unlikely to be a complete artefact and is very probably closely related to genuine protein synthesis. Francis Crick artefactcloselycomplete share on social
Unfortunately it makes the unambiguous determination of triplets by these methods much more difficult than would be the case if there were only one triplet for each amino acid. Francis Crick acidaminocase Change image and share on social
The meaning of this observation is unclear, but it raises the unfortunate possibility of ambiguous triplets; that is, triplets which may code more than one amino acid. However one would certainly expect such triplets to be in a minority. Francis Crick acidambiguousamino share on social
A comparison between the triplets tentatively deduced by these methods with the changes in amino acid sequence produced by mutation shows a fair measure of agreement. Francis Crick acidagreementamino Change image and share on social
